SCHEMBL30916124

SCHEMBL30916124

CN1CCc2nc(C(N)=O)sc2C1c1cccc(-c2cccc(C3c4sc(C(N)=O)nc4CCN3C)c2Cl)c1Cl

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 7/20 0.37
PDCD1 Q15116 5/20 0.36
CD274 Q9NZQ7 5/20 0.36
MAP3K14 Q99558 3/20 0.35
HTR1A P08908 2/20 0.33
HTR7 P34969 2/20 0.33
DRD3 P35462 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30916120 0.95 PDCD1 (0.35) F10PDCD1CD274MAP3K14HTR1A
SCHEMBL30916121 0.88 MAP3K14 (0.34) F10PDCD1CD274MAP3K14HTR1A
SCHEMBL30916140 0.86 CD274 (0.36) F10PDCD1CD274MAP3K14
SCHEMBL30916112 0.85 PDCD1 (0.35) F10PDCD1CD274MAP3K14
SCHEMBL30916127 0.83 PTPN11 (0.35) MAP3K14
SCHEMBL29716115 0.82 F10 (0.33) F10MAP3K14
SCHEMBL30916137 0.77 PARP1 (0.31) PDCD1CD274MAP3K14
SCHEMBL30916122 0.76 MAP3K14 (0.33) F10PDCD1CD274MAP3K14
SCHEMBL30916110 0.74 PDCD1 (0.33) PDCD1CD274
SCHEMBL30916139 0.73 MAP3K14 (0.33) F10PDCD1CD274MAP3K14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111936475-B Immunomodulator, composition and preparation method thereof 贝达药业股份有限公司 2024-05-10 CN claimed
CN-111936475-B Immunomodulator, composition and preparation method thereof 贝达药业股份有限公司 2024-05-10 CN disclosed