Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | TYK2 | P29597 | 10/20 | 0.47 |
| ▸ | JAK1 | P23458 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27295711 | 1.00 | JAK2 (0.48) | JAK2TYK2JAK1KCNH2AXL | |
| SCHEMBL27295069 | 0.93 | JAK2 (0.48) | JAK2TYK2JAK1KCNH2AXL | |
| SCHEMBL27419078 | 0.90 | JAK3 (0.50) | JAK2TYK2JAK1KCNH2MAPT | |
| SCHEMBL27295670 | 0.89 | TYK2 (0.48) | JAK2TYK2JAK1KCNH2AXL | |
| SCHEMBL30923150 | 0.89 | TYK2 (0.48) | JAK2TYK2JAK1KCNH2AXL | |
| SCHEMBL27290127 | 0.89 | JAK1 (0.48) | JAK2TYK2JAK1KCNH2AXL | |
| SCHEMBL27292517 | 0.88 | TYK2 (0.54) | JAK2TYK2JAK1KCNH2MAPT | |
| SCHEMBL30923319 | 0.87 | TYK2 (0.50) | JAK2TYK2JAK1KCNH2MAPT | |
| SCHEMBL30923199 | 0.87 | TYK2 (0.51) | JAK2TYK2JAK1KCNH2MAPT | |
| SCHEMBL27293829 | 0.87 | TYK2 (0.51) | JAK2TYK2JAK1KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4618975-A2 | INHIBITORS OF TYK2 | Vyrnwy Therapeutics, Inc. (US) | 2025-09-24 | — | — | EP | disclosed |
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |