Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 20/20 | 0.64 |
| ▸ | JAK3 | P52333 | 19/20 | 0.64 |
| ▸ | JAK1 | P23458 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007 | 0.88 | JAK2 (0.53) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL2634439 | 0.78 | JAK2 (1.00) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL15221135 | 0.78 | JAK2 (0.53) | JAK2PTK2JAK3 | |
| SCHEMBL2634395 | 0.77 | JAK3 (1.00) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL19111 | 0.77 | JAK2 (0.56) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL3764548 | 0.77 | JAK2 (1.00) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL2634635 | 0.76 | JAK2 (1.00) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL24181 | 0.76 | JAK2 (0.56) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL2634487 | 0.76 | JAK2 (1.00) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL15416863 | 0.75 | JAK2 (0.77) | JAK2PTK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609098-A1 | TRIAZOLOPYRAZINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025186-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |