Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3078753 | 0.89 | PTGDR2 (0.53) | PTGDR2CYP2C9PTGDRCYP3A4HSD11B1 | |
| SCHEMBL3090539 | 0.88 | PTGDR2 (0.38) | PTGDR2CYP2C9PTGDRHSD11B1TBXA2R | |
| SCHEMBL3084777 | 0.86 | PTGDR2 (0.46) | PTGDR2CYP2C9PTGDRCYP3A4HSD11B1 | |
| SCHEMBL3088635 | 0.82 | PTGDR2 (0.54) | PTGDR2CYP2C9PTGDRCYP3A4TBXA2R | |
| SCHEMBL3090480 | 0.81 | PTGDR2 (0.51) | PTGDR2CYP2C9PTGDRCYP3A4TBXA2R | |
| SCHEMBL3089086 | 0.81 | PTGDR2 (0.53) | PTGDR2CYP2C9PTGDRCYP3A4TBXA2R | |
| SCHEMBL3090409 | 0.80 | PTGDR2 (0.44) | PTGDR2CYP2C9PTGDRCYP3A4HSD11B1 | |
| SCHEMBL3092531 | 0.79 | PTGDR2 (0.60) | PTGDR2CYP2C9PTGDRCYP3A4TBXA2R | |
| SCHEMBL3089687 | 0.79 | PTGDR2 (0.51) | PTGDR2CYP2C9PTGDRCYP3A4TBXA2R | |
| SCHEMBL3085299 | 0.78 | PTGDR2 (0.52) | PTGDR2CYP2C9PTGDRCYP3A4TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023864-B2 | Indole derivatives as CRTH2 receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-05-05 | — | — | US | disclosed |
| US-20130150398-A1 | Indole Derivatives as CRTH2 Receptor Antagonists | MERCK SHARP & DOHME LLC | 2013-06-13 | — | — | US | disclosed |
| US-8394819-B2 | Indole derivatives as CRTH2 receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-03-12 | — | — | US | disclosed |
| US-20100234415-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150398-A1 | Indole Derivatives as CRTH2 Receptor Antagonists | PTGER2, PTGDR2, PTGDR | PTGDR2 2/4885CYP2C9 1320/4885PTGDR 3/4885 |
| US-20100234415-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | PTGER2, PTGDR2, PTGDR | PTGDR2 2/4885CYP2C9 1320/4885PTGDR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.