Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.48 |
| ▸ | MTOR | P42345 | 4/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 3/20 | 0.42 |
| ▸ | BMX | P51813 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21561109 | 1.00 | PIK3CA (0.48) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL21552718 | 0.88 | PIK3CA (0.42) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL30925839 | 0.88 | PIK3CA (0.42) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL30925792 | 0.88 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL21552689 | 0.88 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL21552731 | 0.81 | PIK3CA (0.48) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL21485290 | 0.77 | PIK3CA (0.55) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL16719220 | 0.77 | PIK3CA (0.76) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL30925805 | 0.77 | PIK3CA (0.47) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL21561154 | 0.77 | PIK3CA (0.47) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118206551-A | Quinoline compounds, their preparation and their use as antimalarial agents | 美国卫生和人力服务部 | 2024-06-18 | — | — | CN | disclosed |