Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.50 |
| ▸ | JAK3 | P52333 | 18/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 14/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24265 | 0.85 | JAK2 (0.40) | JAK2JAK3PTK2PSEN1PSEN2 | |
| SCHEMBL19966 | 0.76 | DYRK1A (0.47) | JAK2JAK3PTK2 | |
| SCHEMBL19742 | 0.73 | JAK2 (0.40) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL21595 | 0.70 | SYK (0.42) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL15210625 | 0.68 | JAK2 (0.47) | JAK2JAK3PTK2 | |
| SCHEMBL2634313 | 0.67 | JAK2 (1.00) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL20350 | 0.66 | JAK2 (0.43) | JAK2JAK3PTK2 | |
| SCHEMBL3770962 | 0.65 | JAK2 (0.81) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3764604 | 0.65 | JAK2 (1.00) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3212704 | 0.64 | JAK2 (0.67) | JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609098-A1 | TRIAZOLOPYRAZINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025186-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |