Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17437845 | 0.88 | KDM4E (0.47) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL16370033 | 0.88 | KDM4E (0.53) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL16369955 | 0.84 | KDM4E (0.52) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL9941921 | 0.83 | KDM4E (0.49) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL14739137 | 0.83 | KDM4E (0.49) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL731532 | 0.82 | CSF1R (0.49) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL17437968 | 0.82 | KDM4E (0.50) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL30935502 | 0.81 | KDM4E (0.47) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL25967061 | 0.81 | KDM4E (0.47) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL19697643 | 0.81 | KDM4E (0.51) | GAAKDM4EGLAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630424-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | Third Harmonic Bio, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |