Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.79 |
| ▸ | TTK | P33981 | 4/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23779284 | 1.00 | CHRM4 (0.79) | CHRM4TTKLRRK2KDM4E | |
| SCHEMBL23779371 | 0.96 | CHRM4 (0.79) | CHRM4TTKLRRK2KDM4E | |
| SCHEMBL31058686 | 0.96 | CHRM4 (0.79) | CHRM4TTKLRRK2KDM4E | |
| SCHEMBL30935859 | 0.92 | CHRM4 (0.73) | CHRM4TTKLRRK2 | |
| SCHEMBL30935822 | 0.92 | CHRM4 (0.79) | CHRM4TTKLRRK2 | |
| SCHEMBL23779261 | 0.92 | CHRM4 (0.73) | CHRM4TTKLRRK2 | |
| SCHEMBL23779333 | 0.92 | CHRM4 (0.79) | CHRM4TTKLRRK2 | |
| SCHEMBL20599438 | 0.90 | CHRM4 (0.72) | CHRM4TTKLRRK2 | |
| SCHEMBL20602587 | 0.90 | CHRM4 (0.72) | CHRM4TTKLRRK2 | |
| SCHEMBL22160120 | 0.90 | CHRM4 (0.72) | CHRM4TTKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3873467-B1 | 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME LLC (US) | 2024-08-28 | — | — | EP | claimed |
| US-11970479-B2 | 3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor | MERCK SHARP & DOHME LLC (US) | 2024-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11970479-B2 | 3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor | CHRM4, CHRM3, CHRM1 | CHRM4 1/4885TTK 1581/4885LRRK2 1541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.