SCHEMBL30936253

SCHEMBL30936253

CCc1cc(Nc2ncc(Cl)c(Nc3ccc(OC)cc3NS(C)(=O)=O)n2)c(OC)cc1N1CCC(N2CCN(CCOc3c(F)ccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)CC1

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 12/20 0.52
▸ CRBN Q96SW2 1/20 0.52
▸ PTK2 Q05397 2/20 0.46
▸ ALK Q9UM73 7/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30936221 0.94 EGFR (0.52) EGFRCRBNPTK2ALK
SCHEMBL30936283 0.93 EGFR (0.51) EGFRCRBNPTK2ALK
SCHEMBL30936302 0.92 EGFR (0.49) EGFRCRBNPTK2ALK
SCHEMBL30936294 0.92 EGFR (0.56) EGFRCRBNPTK2ALK
SCHEMBL30936837 0.90 EGFR (0.56) EGFRCRBNPTK2ALK
SCHEMBL30936776 0.89 EGFR (0.57) EGFRCRBNPTK2ALK
SCHEMBL30937108 0.89 EGFR (0.55) EGFRCRBNPTK2ALK
SCHEMBL30936369 0.88 ALK (0.50) EGFRCRBNPTK2ALK
SCHEMBL30936223 0.88 EGFR (0.54) EGFRCRBNPTK2ALK
SCHEMBL30936809 0.88 EGFR (0.69) EGFRCRBNPTK2ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024072178-A1 COMPOUND FOR TARGETED PROTEIN DEGRADATION, AND USE THEREOF (주)사이러스테라퓨틱스 2024-04-04 — — WO claimed
WO-2024072178-A1 COMPOUND FOR TARGETED PROTEIN DEGRADATION, AND USE THEREOF (주)사이러스테라퓨틱스 2024-04-04 — — WO disclosed
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