Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.74 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.74 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9914944 | 0.99 | CYP3A4 (0.75) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL15164805 | 0.90 | CYP3A4 (0.78) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL15164819 | 0.90 | CYP3A4 (0.78) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL16440228 | 0.89 | CYP3A4 (0.77) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL9914888 | 0.88 | CYP3A4 (0.75) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL9914890 | 0.88 | CYP2D6 (0.75) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL9914945 | 0.86 | CYP3A4 (0.72) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL14754253 | 0.86 | CYP3A4 (0.67) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL13464991 | 0.85 | CYP2C19 (0.88) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL9914891 | 0.85 | CYP3A4 (0.71) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137495-A9 | FOSTEMSAVIR INTERMEDIATES AND PROCESS FOR THE PREPARATION THEREOF | NAVINTA, LLC (US) | 2024-07-25 | — | — | WO | disclosed |
| WO-2024137495-A1 | FOSTEMSAVIR INTERMEDIATES AND PROCESS FOR THE PREPARATION THEREOF | NAVINTA, LLC (US) | 2024-06-27 | — | — | WO | disclosed |