Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.74 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.43 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3094033 | 1.00 | HDAC1 (0.74) | HDAC1HDAC2HDAC3TNIKTRPV1 | |
| SCHEMBL3098436 | 0.92 | HDAC1 (0.72) | HDAC1HDAC2HDAC3TNIKTRPV1 | |
| SCHEMBL3098427 | 0.92 | HDAC1 (0.72) | HDAC1HDAC2HDAC3TNIKTRPV1 | |
| SCHEMBL3104954 | 0.92 | HDAC1 (0.86) | HDAC1HDAC2HDAC3TNIKTRPV1 | |
| SCHEMBL3104936 | 0.92 | HDAC1 (0.86) | HDAC1HDAC2HDAC3TNIKTRPV1 | |
| SCHEMBL3105150 | 0.92 | HDAC1 (0.86) | HDAC1HDAC2HDAC3CYP1A2CYP3A4 | |
| SCHEMBL3105137 | 0.92 | HDAC1 (0.86) | HDAC1HDAC2HDAC3CYP1A2CYP3A4 | |
| SCHEMBL3088008 | 0.91 | HDAC1 (0.70) | HDAC1HDAC2HDAC3CYP1A2CYP3A4 | |
| SCHEMBL3088007 | 0.91 | HDAC1 (0.70) | HDAC1HDAC2HDAC3CYP1A2CYP3A4 | |
| SCHEMBL3095806 | 0.90 | HDAC1 (0.70) | HDAC1HDAC2HDAC3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238103-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-10-13 | — | — | EP | disclosed |
| US-7795315-B2 | N-(2-amino-phenyl)-amide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20090203681-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | US | disclosed |
| WO-2009095324-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203681-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | MKI67, API5, BAD | HDAC1 815/4885HDAC2 973/4885HDAC3 1401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.