SCHEMBL30940725

SCHEMBL30940725

Nc1ncnc2c1c(-c1nc(Cc3ccccc3)cs1)cn2[C@@H]1C[C@H]([C@@H]2CCNC2)[C@@H](O)[C@H]1O

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 13/20 0.45
▸ EGFR P00533 6/20 0.45
▸ LCK P06239 3/20 0.41
▸ ABL1 P00519 5/20 0.41
▸ ABL2 P42684 5/20 0.41
▸ CA2 P00918 3/20 0.40
▸ TEK Q02763 2/20 0.40
▸ KDR P35968 1/20 0.40
▸ IGF1R P08069 1/20 0.38
▸ FGR P09769 1/20 0.38
▸ EPHA1 P21709 1/20 0.38
▸ TXK P42681 1/20 0.38
▸ FRK P42685 1/20 0.38
▸ PTK6 Q13882 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30941062 1.00 SRC (0.45) SRCEGFRLCKABL1ABL2
SCHEMBL25048893 1.00 SRC (0.45) SRCEGFRLCKABL1ABL2
SCHEMBL30941076 1.00 SRC (0.45) SRCEGFRLCKABL1ABL2
SCHEMBL25048101 1.00 SRC (0.45) SRCEGFRLCKABL1ABL2
SCHEMBL25048196 0.95 SRC (0.42) SRCEGFRLCKABL1ABL2
SCHEMBL25048543 0.95 SRC (0.42) SRCEGFRLCKABL1ABL2
SCHEMBL30941573 0.95 SRC (0.42) SRCEGFRLCKABL1ABL2
SCHEMBL25048549 0.95 SRC (0.42) SRCEGFRLCKABL1ABL2
SCHEMBL25048864 0.95 SRC (0.43) SRCEGFRLCKABL1ABL2
SCHEMBL30941133 0.95 SRC (0.43) SRCEGFRLCKABL1ABL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250188110-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2025-06-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250188110-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION KMT5A, KMT5B, KMT5C SRC 968/4885EGFR 1687/4885LCK 508/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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