Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CIT | O14578 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5220713 | 0.90 | SMN1; SMN2 (0.36) | SMN1; SMN2KDM4EALDH1A1HPGDATAD2 | |
| SCHEMBL3088370 | 0.89 | MEN1 (0.39) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL3083725 | 0.86 | POLB (0.38) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL1845956 | 0.78 | PIK3CA (0.45) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL5217650 | 0.75 | XIAP (0.37) | NPC1RAB9AALDH1A1ATAD2XIAP | |
| SCHEMBL3092245 | 0.74 | PSEN1 (0.54) | — | |
| SCHEMBL3083657 | 0.74 | PSEN1 (0.47) | SMN1; SMN2NPC1RAB9AGLS | |
| SCHEMBL3098715 | 0.74 | PSEN1 (0.47) | SMN1; SMN2NPC1RAB9AGLS | |
| SCHEMBL3095835 | 0.74 | PSEN1 (0.47) | SMN1; SMN2NPC1RAB9AGLS | |
| SCHEMBL5218151 | 0.73 | POLB (0.39) | ATAD2MEN1POLBKMT2AXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795289-B2 | Use of acylaminothiazole derivatives as therapeutic agents | SANOFI-AVENTIS (FR) | 2010-09-14 | — | — | US | disclosed |
| US-20080051436-A1 | Use of Acylaminothiazole Derivatives as Therapeutic Agents | SANOFI-AVENTIS (FR) | 2008-02-28 | — | — | US | disclosed |
| US-7291636-B2 | Acylaminothiazole derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-11-06 | — | — | US | disclosed |
| US-20050182104-A1 | Acylaminothiazole derivatives, preparation and therapeutic use thereof | SANOFI-SYNTHELABO (FR) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051436-A1 | Use of Acylaminothiazole Derivatives as Therapeutic Agents | BACE1, BACE2, ATG4A | SMN1; SMN2 1047/4885NPC1 3362/4885RAB9A 1660/4885 |
| US-20050182104-A1 | Acylaminothiazole derivatives, preparation and therapeutic use thereof | BACE1, APP, BACE2 | SMN1; SMN2 987/4885NPC1 3147/4885RAB9A 1514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.