Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 18/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 4/20 | 1.00 |
| ▸ | MTOR | P42345 | 3/20 | 1.00 |
| ▸ | PIK3R1 | P27986 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | PDE2A | O00408 | 1/20 | 0.65 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.65 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.65 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.65 |
| ▸ | BRD4 | O60885 | 1/20 | 0.65 |
| ▸ | PDE5A | O76074 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | PIM1 | P11309 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30943704 | 1.00 | PRKDC (1.00) | PRKDCPIK3CAMTORPIK3R1TDP1 | |
| SCHEMBL29374897 | 1.00 | PRKDC (1.00) | PRKDCPIK3CAMTORPIK3R1TDP1 | |
| SCHEMBL610237 | 1.00 | PRKDC (1.00) | PRKDCPIK3CAMTORPIK3R1TDP1 | |
| SCHEMBL31061492 | 0.96 | PRKDC (1.00) | PRKDCPIK3CAMTORPIK3R1TDP1 | |
| SCHEMBL3535232 | 0.89 | PRKDC (1.00) | PRKDCPIK3CAMTORPIK3R1TDP1 | |
| SCHEMBL3538224 | 0.88 | PRKDC (1.00) | PRKDCPIK3CAMTORPIK3R1TDP1 | |
| SCHEMBL3537126 | 0.85 | PRKDC (0.78) | PRKDCPIK3CAMTORPIK3R1TDP1 | |
| SCHEMBL31060675 | 0.85 | PRKDC (1.00) | PRKDCPIK3CAMTORPIK3R1TDP1 | |
| SCHEMBL3538463 | 0.85 | PRKDC (0.78) | PRKDCPIK3CAMTORPIK3R1TDP1 | |
| SCHEMBL3537842 | 0.85 | PRKDC (1.00) | PRKDCPIK3CAMTORPIK3R1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024129605-A1 | SELECTIVE TREATMENT OF CANCERS HAVING HISTONE H3 MUTATIONS OR ABERRANT LEVELS OF DNA OR HISTONE METHYLATION, ACETYLATION OR DEFECTS IN HOMOLOGOUS RECOMBINATION | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2024-06-20 | — | — | WO | disclosed |