Exenatide

SCHEMBL30947451

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GLP1R

The experimentally established mechanism targets of Exenatide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	GLP1R known ✓	P43220	17/20	0.79

▸	GCGR	P47871	9/20	0.68

▸	GIPR	P48546	5/20	0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Exenatide SCHEMBL29352797	0.95	GLP1R (0.75)	GLP1RGCGRGIPR
Exenatide SCHEMBL29350782	0.95	GLP1R (0.86)	GLP1RGCGRGIPR
Exenatide SCHEMBL29710890	0.90	GLP1R (0.81)	GLP1RGCGRGIPR
SCHEMBL29429437	0.90	GLP1R (0.81)	GLP1RGCGRGIPR
Exenatide SCHEMBL20509814	0.90	GLP1R (0.81)	GLP1RGCGRGIPR
Exenatide SCHEMBL29827241	0.90	GLP1R (0.81)	GLP1RGCGRGIPR
Exenatide SCHEMBL14634818	0.90	GLP1R (0.81)	GLP1RGCGRGIPR
SCHEMBL31072728	0.90	GLP1R (0.81)	GLP1RGCGRGIPR
SCHEMBL30181569	0.90	GLP1R (0.73)	GLP1RGCGRGIPR
SCHEMBL30485798	0.90	GLP1R (0.73)	GLP1RGCGRGIPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20250325683-A1	LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE	SCRIPPS RESEARCH INST (US)	2025-10-23	—	—	US	disclosed
US-20250320252-A1	LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE	SCRIPPS RESEARCH INST (US)	2025-10-16	—	—	US	disclosed
US-12329823-B2	Long-acting dual GIP/GLP-1 peptide conjugates and methods of use	THE SCRIPPS RESEARCH INSTITUTE (US)	2025-06-17	—	—	US	disclosed
US-20240148884-A1	LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE	THE SCRIPPS RESEARCH INSTITUTE	2024-05-09	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20240148884-A1	LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE	GLP1R, GIPR, GCGR	GLP1R 1/4885GCGR 3/4885GIPR 2/4885
US-20250325683-A1	LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE	GLP1R, GIPR, GCGR	GLP1R 1/4885GCGR 3/4885GIPR 2/4885
US-12329823-B2	Long-acting dual GIP/GLP-1 peptide conjugates and methods of use	GLP1R, GIPR, GCGR	GLP1R 1/4885GCGR 3/4885GIPR 2/4885
US-20250320252-A1	LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE	GLP1R, GIPR, GCGR	GLP1R 1/4885GCGR 3/4885GIPR 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.