Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15713801 | 0.82 | ERN1 (0.40) | ERN1PRKDCCA1CA2CA9 | |
| SCHEMBL24233251 | 0.79 | — | — | |
| SCHEMBL13814618 | 0.77 | ERN1 (0.36) | ERN1CA1CA2CA9 | |
| SCHEMBL29911304 | 0.77 | ERN1 (0.36) | ERN1CA1CA2CA9 | |
| SCHEMBL19269479 | 0.75 | TSHR (0.41) | ERN1PRKDCLMNA | |
| SCHEMBL2226305 | 0.75 | ERN1 (0.39) | ERN1PRKDCCA1CA2CA9 | |
| SCHEMBL32659849 | 0.75 | ERN1 (0.41) | ERN1PRKDCCA1CA2CA9 | |
| SCHEMBL14733521 | 0.75 | ERN1 (0.41) | ERN1PRKDCCA1CA2CA9 | |
| SCHEMBL30952047 | 0.75 | ERN1 (0.35) | ERN1PRKDCLMNA | |
| SCHEMBL31055919 | 0.75 | ERN1 (0.48) | ERN1PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630001-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | Merck Sharp & Dohme LLC (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024123585-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC (US) | 2024-06-13 | — | — | WO | disclosed |