Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27356051 | 0.88 | USP30 (0.45) | PIK3CDUSP30PIM1PIM2BTK | |
| SCHEMBL31043412 | 0.88 | USP30 (0.45) | PIK3CDUSP30PIM1PIM2BTK | |
| SCHEMBL30108729 | 0.85 | USP30 (0.50) | PIK3CDUSP30PIM1PIM2BTK | |
| SCHEMBL27354366 | 0.85 | USP30 (0.50) | PIK3CDUSP30PIM1PIM2BTK | |
| SCHEMBL25858601 | 0.85 | USP30 (0.50) | PIK3CDUSP30PIM1PIM2BTK | |
| SCHEMBL31719414 | 0.85 | IRAK4 (0.47) | IRAK4PIK3CDPDE5AKDM1A | |
| SCHEMBL31043425 | 0.84 | USP30 (0.45) | PIK3CDUSP30PIM1PIM2BTK | |
| SCHEMBL27356058 | 0.84 | USP30 (0.45) | PIK3CDUSP30PIM1PIM2BTK | |
| SCHEMBL30624719 | 0.82 | USP30 (0.43) | PIK3CDUSP30PIM1PIM2BTK | |
| SCHEMBL29131908 | 0.82 | USP30 (0.43) | PIK3CDUSP30PIM1PIM2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4644380-A1 | PYRIDAZINE NLRP3 INHIBITOR COMPOUND, PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Changchun Genescience Pharmaceutical Co., Ltd. (CN) | 2025-11-05 | — | — | EP | disclosed |
| WO-2024140824-A1 | PYRIDAZINE NLRP3 INHIBITOR COMPOUND, PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 长春金赛药业有限责任公司 | 2024-07-04 | — | — | WO | disclosed |