Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25387349 | 0.95 | CYP3A4 (0.46) | CYP3A4NAMPTXDHKMT2ANPC1 | |
| SCHEMBL7469039 | 0.83 | CYP3A4 (0.50) | CYP3A4NAMPTXDHKMT2ANPC1 | |
| SCHEMBL7020232 | 0.82 | KMT2A (0.45) | KMT2ANPC1RAB9AMAPTTDP1 | |
| SCHEMBL29424852 | 0.82 | CYP3A4 (0.49) | CYP3A4NAMPTXDHKMT2ANPC1 | |
| SCHEMBL22533750 | 0.82 | CYP3A4 (0.49) | CYP3A4NAMPTXDHKMT2ANPC1 | |
| SCHEMBL8427411 | 0.77 | CYP3A4 (0.61) | CYP3A4NAMPTXDHKMT2ANPC1 | |
| SCHEMBL22533358 | 0.77 | QPCT (0.50) | KMT2ANPC1RAB9AMAPTTDP1 | |
| SCHEMBL25727792 | 0.77 | HDAC6 (0.43) | CYP3A4KMT2ANPC1RAB9AMAPT | |
| SCHEMBL8802475 | 0.77 | KDM4E (0.54) | KMT2ANPC1RAB9AMAPTTDP1 | |
| SCHEMBL1308200 | 0.77 | NAMPT (0.50) | CYP3A4NAMPTXDHKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113767090-B | Tricyclic compound, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2024-05-28 | — | — | CN | disclosed |