Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Talazoparib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 20/20 | 1.00 |
| ▸ | PARP2 known ✓ | Q9UGN5 | 15/20 | 1.00 |
| ▸ | PARP3 | Q9Y6F1 | 15/20 | 1.00 |
| ▸ | TNKS | O95271 | 2/20 | 1.00 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 1.00 |
| ▸ | PARP16 | Q8N5Y8 | 2/20 | 1.00 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 1.00 |
| ▸ | PARP15 | Q460N3 | 1/20 | 1.00 |
| ▸ | PARP14 | Q460N5 | 1/20 | 1.00 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 1.00 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 1.00 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Talazoparib SCHEMBL30099172 | 1.00 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL2299348 | 1.00 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL16204525 | 1.00 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL30099170 | 1.00 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL23048317 | 1.00 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL2046086 | 1.00 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL24440571 | 1.00 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL2295997 | 1.00 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL30419102 | 1.00 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL29948077 | 1.00 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240180962-A1 | TREATMENT OF CANCER WITH NK CELLS AND A CD20 TARGETED ANTIBODY | GC Cell Corporation (KR) | 2024-06-06 | — | — | US | disclosed |