Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 5/20 | 0.34 |
| ▸ | BRD4 | O60885 | 5/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | BRD2 | P25440 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.33 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30955561 | 0.89 | ERN1 (0.43) | ERN1TNK2MAP4K2JAK2JAK1 | |
| SCHEMBL30955498 | 0.89 | ERN1 (0.43) | ERN1TNK2MAP4K2JAK2BRD4 | |
| SCHEMBL30955560 | 0.89 | ERN1 (0.43) | ERN1TNK2MAP4K2JAK2BRD4 | |
| SCHEMBL30955490 | 0.89 | ERN1 (0.43) | ERN1TNK2MAP4K2JAK2BRD4 | |
| SCHEMBL30955493 | 0.87 | ERN1 (0.54) | ERN1TNK2MAP4K2MAPK8MAPK14 | |
| SCHEMBL30955556 | 0.87 | ERN1 (0.43) | ERN1TNK2MAP4K2JAK2BRD4 | |
| SCHEMBL30955548 | 0.86 | ERN1 (0.43) | ERN1TNK2MAP4K2JAK2BRD4 | |
| SCHEMBL30955501 | 0.85 | ERN1 (0.39) | ERN1TNK2MAP4K2MAPK8MAPK14 | |
| SCHEMBL30955594 | 0.85 | ERN1 (0.45) | ERN1TNK2MAP4K2MAPK8MAPK14 | |
| SCHEMBL30955492 | 0.85 | ERN1 (0.42) | ERN1TNK2MAP4K2JAK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024131893-A1 | IRE1α SMALL MOLECULE INHIBITORS | SHANGHAI YI ZHONG XING BIOTECHNOLOGY CO., LTD. (CN) | 2024-06-27 | — | — | WO | claimed |
| WO-2024131893-A1 | IRE1α SMALL MOLECULE INHIBITORS | SHANGHAI YI ZHONG XING BIOTECHNOLOGY CO., LTD. (CN) | 2024-06-27 | — | — | WO | disclosed |