Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 2/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 11/20 | 0.53 |
| ▸ | JAK1 | P23458 | 8/20 | 0.53 |
| ▸ | JAK2 | O60674 | 7/20 | 0.53 |
| ▸ | TYK2 | P29597 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | TTK | P33981 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956456 | 0.93 | MAP3K7 (0.58) | MAP3K7FLT4MAPK1FLT3MAP2K1 | |
| SCHEMBL30956533 | 0.88 | JAK2 (0.51) | MAP3K7FLT4MAPK1FLT3MAP2K1 | |
| SCHEMBL30956385 | 0.88 | CDK2 (0.58) | MAP3K7FLT4MAPK1MAP2K1JAK3 | |
| SCHEMBL30956483 | 0.87 | MAP3K7 (0.46) | MAP3K7FLT4MAPK1FLT3MAP2K1 | |
| SCHEMBL28605509 | 0.86 | MAP3K7 (0.52) | MAP3K7FLT4MAPK1FLT3MAP2K1 | |
| SCHEMBL24852784 | 0.84 | MAP3K7 (0.55) | MAP3K7FLT4MAPK1FLT3MAP2K1 | |
| SCHEMBL30956585 | 0.82 | CDK2 (0.55) | MAP3K7FLT4MAPK1MAP2K1JAK3 | |
| SCHEMBL30956564 | 0.82 | JAK2 (0.56) | MAP3K7FLT3JAK3JAK1JAK2 | |
| SCHEMBL30956393 | 0.81 | JAK2 (0.53) | MAP3K7FLT4JAK3JAK1JAK2 | |
| SCHEMBL30956578 | 0.81 | JAK2 (0.58) | FLT4JAK3JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118999-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-118955477-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118903141-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-118903142-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-113227074-B | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-118388457-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |