Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.66 |
| ▸ | JAK3 | P52333 | 18/20 | 0.66 |
| ▸ | JAK1 | P23458 | 17/20 | 0.66 |
| ▸ | TYK2 | P29597 | 10/20 | 0.66 |
| ▸ | STAT3 | P40763 | 7/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956478 | 0.92 | JAK3 (0.54) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL30956577 | 0.89 | JAK2 (0.53) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL30956440 | 0.89 | JAK3 (0.57) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL30956481 | 0.86 | JAK3 (0.49) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL30956586 | 0.84 | JAK1 (0.60) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL22098062 | 0.84 | JAK2 (0.67) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL30956533 | 0.81 | JAK2 (0.51) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL30956395 | 0.80 | JAK3 (0.44) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL30956429 | 0.80 | JAK2 (0.47) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL28605522 | 0.80 | JAK3 (0.47) | JAK2JAK3JAK1TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118999-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-118955477-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118903141-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-118903142-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-113227074-B | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-118388457-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |