Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956465 | 0.91 | NPC1 (0.46) | FLT4AURKACDK2MAPK1PTK2 | |
| SCHEMBL30827949 | 0.90 | AURKA (0.47) | FLT4AURKACDK2MAPK1PTK2 | |
| SCHEMBL30956538 | 0.83 | JAK2 (0.45) | FLT4AURKACDK2MAPK1PTK2 | |
| SCHEMBL28611273 | 0.82 | CDK2 (0.43) | FLT4AURKACDK2MAPK1PTK2 | |
| SCHEMBL30956572 | 0.81 | JAK1 (0.58) | FLT4CDK2JAK2JAK1KDR | |
| SCHEMBL30956505 | 0.80 | CDK2 (0.39) | FLT4AURKACDK2PTK2JAK2 | |
| SCHEMBL24852536 | 0.80 | CDK2 (0.48) | FLT4AURKACDK2MAPK1JAK2 | |
| SCHEMBL30956393 | 0.78 | JAK2 (0.53) | FLT4JAK2JAK1JAK3TYK2 | |
| SCHEMBL30956450 | 0.78 | JAK3 (0.51) | FLT4CDK2MAPK1JAK2JAK1 | |
| SCHEMBL30956426 | 0.78 | FLT4 (0.46) | FLT4CDK2PTK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118999-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-118955477-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118903141-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-118903142-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-113227074-B | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-118388457-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |