Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.46 |
| ▸ | JAK1 | P23458 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 8/20 | 0.44 |
| ▸ | TYK2 | P29597 | 3/20 | 0.44 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.43 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CDK7 | P50613 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 3/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956450 | 0.92 | JAK3 (0.51) | JAK2JAK1JAK3TYK2NUAK1 | |
| SCHEMBL28919841 | 0.90 | JAK2 (0.40) | JAK2JAK1JAK3TYK2NUAK1 | |
| SCHEMBL30956612 | 0.89 | JAK3 (0.49) | JAK2JAK1JAK3TYK2NUAK1 | |
| SCHEMBL30956426 | 0.89 | FLT4 (0.46) | JAK2JAK1JAK3TYK2NUAK1 | |
| SCHEMBL30956572 | 0.88 | JAK1 (0.58) | JAK2JAK1JAK3TYK2CDK2 | |
| SCHEMBL30956543 | 0.88 | FLT4 (0.54) | JAK2JAK1JAK3TYK2IGF1R | |
| SCHEMBL30956526 | 0.88 | JAK3 (0.47) | JAK2JAK1JAK3TYK2NUAK1 | |
| SCHEMBL30956469 | 0.88 | JAK3 (0.42) | JAK2JAK1JAK3TYK2NUAK1 | |
| Hydrochloric Acid SCHEMBL30956501 | 0.87 | NUAK1 (0.55) | JAK2JAK1JAK3TYK2NUAK1 | |
| SCHEMBL30956410 | 0.86 | JAK1 (0.43) | JAK2JAK1JAK3TYK2NUAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118999-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-118955477-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118903141-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-118903142-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-113227074-B | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-118388457-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |