Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 10/20 | 0.55 |
| ▸ | JAK1 | P23458 | 9/20 | 0.55 |
| ▸ | JAK2 | O60674 | 9/20 | 0.55 |
| ▸ | FLT4 | P35916 | 6/20 | 0.50 |
| ▸ | KDR | P35968 | 6/20 | 0.50 |
| ▸ | TYK2 | P29597 | 3/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956537 | 0.93 | JAK3 (0.58) | CDK1IGF1RCDK2CDK8CDK7 | |
| Lithium SCHEMBL30956422 | 0.92 | FLT4 (0.58) | CDK1IGF1RCDK2CDK8CDK7 | |
| SCHEMBL30956536 | 0.92 | JAK3 (0.56) | CDK1IGF1RCDK2CDK8CDK7 | |
| SCHEMBL30956585 | 0.89 | CDK2 (0.55) | CDK1IGF1RCDK2CDK8CDK7 | |
| SCHEMBL30956399 | 0.89 | IGF1R (0.58) | CDK1IGF1RCDK2CDK8CDK7 | |
| SCHEMBL30956567 | 0.88 | JAK3 (0.54) | CDK1IGF1RCDK2CDK8CDK7 | |
| SCHEMBL30956452 | 0.87 | CDK1 (0.51) | CDK1IGF1RCDK2CDK8CDK7 | |
| SCHEMBL30891574 | 0.87 | CDK1 (0.54) | CDK1IGF1RCDK2CDK8CDK7 | |
| SCHEMBL30956582 | 0.87 | JAK2 (0.60) | CDK1CDK2CDK8CDK7CDK9 | |
| SCHEMBL30956373 | 0.86 | JAK3 (0.53) | JAK3JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118999-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-118955477-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118903141-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-118903142-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-113227074-B | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-118388457-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |