Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | ULK1 | O75385 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ATF1 | P18846 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24179307 | 0.86 | MAPK3 (0.49) | MAP4K1MAPK3 | |
| SCHEMBL23932620 | 0.85 | ALK (0.53) | MAP4K1PTK2EGFRALKINSR | |
| SCHEMBL30958105 | 0.85 | MAP4K1 (0.45) | MAP4K1MAPK3PTK2ULK1EGFR | |
| SCHEMBL30958143 | 0.85 | MAPK3 (0.42) | MAP4K1MAPK3PTK2ULK1EGFR | |
| SCHEMBL30776706 | 0.84 | ZAP70 (0.43) | MAP4K1ULK1EGFRALKINSR | |
| SCHEMBL17411147 | 0.82 | MAP4K1 (0.50) | MAP4K1MAPK3PTK2ULK1EGFR | |
| SCHEMBL29833006 | 0.82 | MAP4K1 (0.50) | MAP4K1MAPK3PTK2ULK1EGFR | |
| SCHEMBL28969579 | 0.78 | ALK (0.53) | PTK2ULK1EGFRALKINSR | |
| SCHEMBL30184338 | 0.78 | ALK (0.53) | PTK2ULK1EGFRALKINSR | |
| SCHEMBL28969589 | 0.77 | PTK2 (0.45) | MAP4K1MAPK3PTK2ULK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024094171-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2024-05-10 | — | — | WO | disclosed |