Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 19/20 | 0.83 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | ELOC | Q15369 | 3/20 | 0.50 |
| ▸ | ELOB | Q15370 | 3/20 | 0.50 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.50 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25898820 | 1.00 | VHL (0.83) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL27285483 | 0.93 | VHL (0.84) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL22525885 | 0.93 | VHL (0.84) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL23945800 | 0.93 | VHL (0.84) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL25123315 | 0.93 | VHL (0.84) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL25898334 | 0.92 | VHL (0.82) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL30960011 | 0.92 | VHL (0.82) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL24461192 | 0.91 | VHL (0.81) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL27063314 | 0.91 | VHL (0.81) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL24654308 | 0.91 | VHL (1.00) | VHLELOCELOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141570-A9 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |