SCHEMBL30962729

SCHEMBL30962729

COc1nc(Nc2ccc([C@H]3CCCN(C)C3)c(C)c2)ncc1C(=O)Nc1c(Cl)cccc1Br

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 9/20 0.43
▸ SIK1 P57059 2/20 0.42
▸ SIK2 Q9H0K1 2/20 0.42
▸ SIK3 Q9Y2K2 2/20 0.42
▸ WEE1 P30291 2/20 0.42
▸ LCK P06239 3/20 0.41
▸ TNK2 Q07912 3/20 0.41
▸ JAK3 P52333 2/20 0.41
▸ KDR P35968 1/20 0.41
▸ TEK Q02763 1/20 0.41
▸ MAPK14 Q16539 1/20 0.41
▸ HCK P08631 1/20 0.40
▸ FGFR1 P11362 1/20 0.40
▸ MAP4K1 Q92918 1/20 0.38
▸ PTK2 Q05397 1/20 0.38
▸ BTK Q06187 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30962711 1.00 SRC (0.43) SRCSIK1SIK2SIK3WEE1
SCHEMBL30962855 1.00 SRC (0.43) SRCSIK1SIK2SIK3WEE1
SCHEMBL30962635 0.96 WEE1 (0.46) SRCSIK1SIK2SIK3WEE1
SCHEMBL30962914 0.96 WEE1 (0.46) SRCSIK1SIK2SIK3WEE1
SCHEMBL30962935 0.96 WEE1 (0.46) SRCSIK1SIK2SIK3WEE1
SCHEMBL30962615 0.94 WEE1 (0.48) SRCSIK1SIK2SIK3WEE1
SCHEMBL30962751 0.94 WEE1 (0.48) SRCSIK1SIK2SIK3WEE1
SCHEMBL30962620 0.94 WEE1 (0.48) SRCSIK1SIK2SIK3WEE1
SCHEMBL30962787 0.91 WEE1 (0.51) SRCSIK1SIK2SIK3WEE1
SCHEMBL27313554 0.91 WEE1 (0.51) SRCSIK1SIK2SIK3WEE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4642767-A1 PYRIMIDINE CARBOXAMIDE COMPOUNDS Acrivon Therapeutics, Inc. (US) 2025-11-05 — — EP disclosed
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