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SCHEMBL30965631

SCHEMBL30965631

COc1cc(C(=O)NC2CC3(CCN(CC4CCN(c5cc(OC)c(NC6CCC(=O)NC6=O)cc5F)CC4)CC3)C2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C

nearest known ligand 0.61

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ PLK1 P53350 17/20 0.61
▸ BRD4 O60885 2/20 0.61
▸ BRDT Q58F21 2/20 0.61
▸ RAD52 P43351 1/20 0.48
▸ PLK3 Q9H4B4 1/20 0.46
▸ PLK2 Q9NYY3 1/20 0.46
▸ ALK Q9UM73 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30965588 0.98 PLK1 (0.61) PLK1BRD4BRDTRAD52ALK
SCHEMBL30965776 0.94 PLK1 (0.60) PLK1BRD4BRDTRAD52ALK
SCHEMBL25259265 0.91 PLK1 (0.61) PLK1BRD4BRDTRAD52ALK
SCHEMBL25033916 0.91 PLK1 (0.61) PLK1BRD4BRDTRAD52ALK
SCHEMBL30965589 0.90 PLK1 (0.68) PLK1BRD4BRDTRAD52PLK3
SCHEMBL30965599 0.88 PLK1 (0.66) PLK1BRD4BRDTRAD52ALK
SCHEMBL25035203 0.88 PLK1 (0.63) PLK1BRD4BRDTRAD52ALK
SCHEMBL25034666 0.88 PLK1 (0.61) PLK1BRD4BRDTRAD52PLK3
SCHEMBL30965637 0.88 PLK1 (0.61) PLK1BRD4BRDTRAD52PLK3
SCHEMBL30965665 0.88 PLK1 (0.68) PLK1BRD4BRDTRAD52PLK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658658-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND Uppthera, Inc. (KR) 2025-12-10 — — EP disclosed
WO-2024162828-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2024-08-08 — — WO disclosed