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SCHEMBL30965737

SCHEMBL30965737

COc1cc(C(=O)NC2CCC(N(C)CC3CCN(c4cccc(N5CCC(=O)NC5=O)c4)CC3)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C

nearest known ligand 0.64

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PLK1 P53350 17/20 0.64
▸ BRD4 O60885 2/20 0.64
▸ BRDT Q58F21 2/20 0.64
▸ RAD52 P43351 1/20 0.51
▸ ALK Q9UM73 1/20 0.48
▸ PLK3 Q9H4B4 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30965620 0.88 PLK1 (0.64) PLK1BRD4BRDTRAD52ALK
SCHEMBL25034696 0.88 PLK1 (0.62) PLK1BRD4BRDTRAD52ALK
SCHEMBL30965605 0.86 PLK1 (0.63) PLK1BRD4BRDTRAD52ALK
SCHEMBL30965627 0.85 PLK1 (0.63) PLK1BRD4BRDTRAD52ALK
SCHEMBL25295077 0.85 PLK1 (0.63) PLK1BRD4BRDTRAD52ALK
SCHEMBL25820258 0.85 PLK1 (0.63) PLK1BRD4BRDTRAD52ALK
SCHEMBL25295076 0.85 PLK1 (0.63) PLK1BRD4BRDTRAD52ALK
SCHEMBL30965770 0.85 PLK1 (0.63) PLK1BRD4BRDTRAD52ALK
SCHEMBL30965577 0.85 PLK1 (0.63) PLK1BRD4BRDTRAD52ALK
SCHEMBL25300654 0.83 PLK1 (0.63) PLK1BRD4BRDTRAD52ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658658-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND Uppthera, Inc. (KR) 2025-12-10 — — EP disclosed
WO-2024162828-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2024-08-08 — — WO disclosed