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SCHEMBL30965780

SCHEMBL30965780

COc1cc(C(=O)NN2CCC(CCN3CCN(c4ccc(NC5CCC(=O)NC5=O)c(F)c4)CC3)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ PLK1 P53350 18/20 0.56
▸ BRD4 O60885 2/20 0.56
▸ BRDT Q58F21 2/20 0.56
▸ TTK P33981 3/20 0.45
▸ RAD52 P43351 1/20 0.44
▸ PLK4 O00444 1/20 0.43
▸ GAK O14976 1/20 0.43
▸ STK33 Q9BYT3 1/20 0.43
▸ PLK3 Q9H4B4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30965555 0.95 PLK1 (0.58) PLK1BRD4BRDTTTKRAD52
SCHEMBL30965654 0.94 PLK1 (0.57) PLK1BRD4BRDTRAD52
SCHEMBL30965727 0.94 PLK1 (0.57) PLK1BRD4BRDTRAD52PLK3
SCHEMBL30965567 0.94 PLK1 (0.57) PLK1BRD4BRDTRAD52PLK3
SCHEMBL30965525 0.94 PLK1 (0.57) PLK1BRD4BRDTRAD52
SCHEMBL31376455 0.93 PLK1 (0.56) PLK1BRD4BRDTRAD52
SCHEMBL30965785 0.93 PLK1 (0.56) PLK1BRD4BRDTRAD52
SCHEMBL30965628 0.93 PLK1 (0.56) PLK1BRD4BRDTRAD52
SCHEMBL30965557 0.92 PLK1 (0.55) PLK1BRD4BRDTRAD52PLK3
SCHEMBL30965520 0.92 PLK1 (0.46) PLK1BRD4BRDTPLK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658658-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND Uppthera, Inc. (KR) 2025-12-10 — — EP disclosed
WO-2024162828-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2024-08-08 — — WO disclosed