Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30967504 | 0.99 | SCN9A (0.34) | SCN9AGRM2PSEN1PSEN2APH1B | |
| SCHEMBL30967631 | 0.88 | SCN9A (0.34) | SCN9A | |
| SCHEMBL30967583 | 0.88 | HRH3 (0.32) | SCN9AHRH3 | |
| Hydrochloric Acid SCHEMBL30967494 | 0.87 | SCN9A (0.33) | SCN9A | |
| SCHEMBL30967529 | 0.84 | HRH3 (0.32) | SCN9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30967533 | 0.84 | HRH3 (0.34) | SCN9AHRH3CYP3A4 | |
| SCHEMBL30967486 | 0.84 | HRH3 (0.32) | SCN9AHRH3CYP3A4 | |
| Hydrochloric Acid SCHEMBL30967518 | 0.83 | HRH3 (0.33) | SCN9AGRM2PSEN1PSEN2APH1B | |
| SCHEMBL30967541 | 0.80 | HRH3 (0.30) | HRH3 | |
| Hydrochloric Acid SCHEMBL30967477 | 0.78 | DRD3 (0.35) | GRM2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4615838-A1 | SUBSTITUTED BI-AND TRICYCLIC HSET INHIBITORS | Merck Patent GmbH (DE) | 2025-09-17 | — | — | EP | disclosed |
| WO-2024099898-A1 | SUBSTITUTED BI-AND TRICYCLIC HSET INHIBITORS | MERCK PATENT GMBH (DE) | 2024-05-16 | — | — | WO | disclosed |