Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6255532 | 1.00 | CHRM2 (0.38) | CHRM2CHRM1CHRM3BUB1KDM4E | |
| SCHEMBL30204761 | 1.00 | CHRM2 (0.38) | CHRM2CHRM1CHRM3BUB1KDM4E | |
| SCHEMBL25091833 | 1.00 | CHRM2 (0.38) | CHRM2CHRM1CHRM3BUB1KDM4E | |
| SCHEMBL24249006 | 0.85 | TDP1 (0.36) | — | |
| SCHEMBL25712548 | 0.83 | CHRM2 (0.45) | CHRM2CHRM1CHRM3KDM4EMAPT | |
| SCHEMBL23245696 | 0.83 | CHRM2 (0.45) | CHRM2CHRM1CHRM3KDM4EMAPT | |
| SCHEMBL30968059 | 0.82 | CHRM2 (0.35) | CHRM2CHRM1CHRM3BUB1KDM4E | |
| SCHEMBL22323566 | 0.80 | MAPK1 (0.32) | — | |
| SCHEMBL30968027 | 0.80 | DDB1 (0.36) | CHRM2CHRM1CHRM3BUB1KDM4E | |
| SCHEMBL30968082 | 0.79 | CHRM2 (0.41) | CHRM2CHRM1CHRM3KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024131942-A1 | CYCLOPROPANE TLR7 AND TLR8 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海深势唯思科技有限责任公司 | 2024-06-27 | — | — | WO | disclosed |
| CN-118239959-A | Cyclopropane TLR7 and 8 inhibitor and preparation method and application thereof | 上海深势唯思科技有限责任公司 | 2024-06-25 | — | — | CN | disclosed |