Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PHGDH | O43175 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24950110 | 1.00 | CA12 (0.50) | CA12CA1CA2CA9LMNA | |
| SCHEMBL30119787 | 0.76 | PARP1 (0.35) | LMNAKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL30051006 | 0.73 | TLR8 (0.35) | CA12CA1CA2CA9LMNA | |
| SCHEMBL26983763 | 0.73 | TLR8 (0.35) | CA12CA1CA2CA9LMNA | |
| SCHEMBL4298598 | 0.73 | PHGDH (0.59) | CA12CA1CA2CA9PHGDH | |
| SCHEMBL30392625 | 0.72 | MAPK1 (0.47) | KDM4EMAPTALDH1A1CFTRHSD17B10 | |
| SCHEMBL26099039 | 0.72 | MAPK1 (0.47) | KDM4EMAPTALDH1A1CFTRHSD17B10 | |
| SCHEMBL30050566 | 0.71 | PIM1 (0.33) | LMNAKDM4EHTR2AHTR2CPARP1 | |
| SCHEMBL26983719 | 0.71 | PIM1 (0.33) | LMNAKDM4EHTR2AHTR2CPARP1 | |
| SCHEMBL10960030 | 0.71 | CA12 (0.48) | CA12CA1CA2CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227071-B | Amide-substituted heterocyclic compounds for the treatment of disorders associated with modulation of IL-12, IL-23 and/or IFN-alpha | 百时美施贵宝公司 | 2024-06-25 | — | — | CN | disclosed |