Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.50 |
| ▸ | RET | P07949 | 9/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | KIF5B | P33176 | 6/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.45 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.45 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8230611 | 1.00 | EGFR (0.51) | EGFRMAP4K4RETKDRKIF5B | |
| SCHEMBL4417590 | 0.93 | PDE5A (0.51) | EGFRMAP4K4RETKDRKIF5B | |
| SCHEMBL30103402 | 0.86 | PDE5A (0.57) | EGFRMAP4K4RETKDRPDE5A | |
| SCHEMBL3166753 | 0.86 | PDE5A (0.57) | EGFRMAP4K4RETKDRPDE5A | |
| SCHEMBL29801726 | 0.83 | EGFR (0.53) | EGFRRETKDRKIF5BATM | |
| SCHEMBL29761271 | 0.83 | MAP4K4 (0.52) | EGFRMAP4K4RETKDRPDE5A | |
| SCHEMBL160593 | 0.83 | MAP4K4 (0.52) | EGFRMAP4K4RETKDRPDE5A | |
| SCHEMBL216888 | 0.83 | EGFR (0.53) | EGFRRETKDRKIF5BATM | |
| SCHEMBL20813476 | 0.81 | EGFR (0.52) | EGFRRETKDRKIF5BATM | |
| SCHEMBL12447316 | 0.81 | EGFR (0.52) | EGFRRETKDRKIF5BGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118063399-A | Method for synthesizing N- (3-chloro-4-fluorophenyl) -6-hydroxy-7-methoxy-4-quinazolinamine | 杭州微流汇科技有限公司 | 2024-05-24 | — | — | CN | claimed |