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Aviptadil

Aviptadil

SCHEMBL30969141

CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)O

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C

The experimentally established mechanism targets of Aviptadil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ VIPR1 P32241 4/20 0.72
▸ VIPR2 P41587 6/20 0.69
▸ GLP1R P43220 8/20 0.66
▸ CALCR P30988 3/20 0.64
▸ CCKBR P32239 1/20 0.64
▸ CRHR1 P34998 1/20 0.63
▸ CRHR2 Q13324 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Vasoactive Intestinal Peptide SCHEMBL3041046 1.00 VIPR1 (0.72) VIPR1VIPR2GLP1RCALCRCCKBR
SCHEMBL31331832 0.97 VIPR1 (0.68) VIPR1VIPR2GLP1RCALCRCCKBR
SCHEMBL30970990 0.96 GLP1R (0.71) VIPR1VIPR2GLP1RCALCRCCKBR
SCHEMBL29939655 0.96 GLP1R (0.70) VIPR1GLP1RCALCRCCKBR
SCHEMBL29939727 0.95 GLP1R (0.72) VIPR1GLP1RCALCRCCKBR
SCHEMBL30536940 0.95 VIPR1 (0.64) VIPR1VIPR2GLP1RCALCRCCKBR
SCHEMBL31332028 0.95 VIPR2 (0.66) VIPR1VIPR2GLP1RCALCRCCKBR
SCHEMBL29499682 0.95 GLP1R (0.70) VIPR1GLP1RCALCRCCKBRCRHR1
SCHEMBL29516852 0.94 VIPR1 (0.70) VIPR1VIPR2GLP1RCCKBR
SCHEMBL29430436 0.94 VIPR1 (0.70) VIPR1VIPR2GLP1RCCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240210401-A1 METHOD OF USING PACAP AND VIP PEPTIDES FOR DETECTING SHED OR CIRCULATING TUMOR CELLS IN BIOLOGICAL FLUIDS THOMAS JEFFERSON UNIVERSITY 2024-06-27 — — US disclosed
US-20240181014-A1 USE OF AVIPTADIL ALONE OR IN COMBINATION WITH ALPHA LIPOIC ACID AS A THERAPEUTIC MEDICAMENT FOR POST-VIRAL INFECTION SYNDROME ADVITA LIFESCIENCE AG (CH) 2024-06-06 — — US disclosed
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