SCHEMBL30969404

SCHEMBL30969404

CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(NC(=O)NCc3cccnc3)cc2)CC1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 20/20 0.72
CYP2C9 P11712 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28903634 1.00 NAMPT (0.72) NAMPTCYP2C9
SCHEMBL28116171 0.91 NAMPT (0.70) NAMPTCYP2C9
SCHEMBL165810 0.91 NAMPT (0.77) NAMPTCYP2C9
SCHEMBL29230301 0.89 NAMPT (0.72) NAMPT
SCHEMBL17727644 0.86 NAMPT (0.82) NAMPTCYP2C9
SCHEMBL28903619 0.85 NAMPT (0.67) NAMPTCYP2C9
SCHEMBL164753 0.85 NAMPT (0.83) NAMPTCYP2C9
SCHEMBL21132535 0.85 NAMPT (0.83) NAMPTCYP2C9
SCHEMBL29635838 0.85 NAMPT (0.83) NAMPTCYP2C9
SCHEMBL163838 0.84 NAMPT (1.00) NAMPTCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115286617-B PROTAC compound for targeted degradation of NAMPT and application thereof 中国人民解放军海军军医大学 2024-04-30 CN disclosed