Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 17/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12423663 | 0.94 | AKT3 (0.60) | AKT3CNR2ABL1BCR | |
| SCHEMBL2196849 | 0.91 | AKT3 (0.55) | AKT3CNR2 | |
| SCHEMBL13051469 | 0.89 | AKT3 (0.49) | AKT3HDAC1ABL1BCR | |
| SCHEMBL2198416 | 0.88 | AKT3 (0.45) | AKT3ABL1BCR | |
| SCHEMBL12423675 | 0.86 | AKT3 (0.46) | AKT3CNR2 | |
| SCHEMBL12423662 | 0.85 | AKT3 (0.61) | AKT3CNR2ABL1BCR | |
| SCHEMBL3097647 | 0.84 | BTK (0.42) | AKT3CNR2ABL1BCR | |
| SCHEMBL3977667 | 0.83 | AKT3 (0.58) | AKT3CNR2 | |
| SCHEMBL12423276 | 0.83 | AKT3 (0.54) | AKT3CNR2 | |
| SCHEMBL12423664 | 0.82 | AKT3 (0.59) | AKT3CNR2ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803806-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-20070117800-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117800-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | MAP3K20, MAP3K6, MAP4K2 | AKT3 340/4885HDAC1 1547/4885CNR2 2660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.