Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.79 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3098220 | 1.00 | HDAC1 (0.79) | HDAC1HDAC3HDAC2ALDH1A1KDM4E | |
| SCHEMBL3088025 | 0.96 | HDAC1 (0.72) | HDAC1HDAC3HDAC2ALDH1A1KDM4E | |
| SCHEMBL3088020 | 0.96 | HDAC1 (0.72) | HDAC1HDAC3HDAC2ALDH1A1KDM4E | |
| SCHEMBL3087538 | 0.92 | HDAC1 (0.67) | HDAC1HDAC3HDAC2EP300HDAC4 | |
| SCHEMBL3087536 | 0.92 | HDAC1 (0.67) | HDAC1HDAC3HDAC2EP300HDAC4 | |
| SCHEMBL3098883 | 0.92 | HDAC1 (0.84) | HDAC1HDAC3HDAC2ALDH1A1KDM4E | |
| SCHEMBL3098887 | 0.92 | HDAC1 (0.84) | HDAC1HDAC3HDAC2ALDH1A1KDM4E | |
| SCHEMBL3095140 | 0.91 | HDAC1 (0.86) | HDAC1HDAC3HDAC2ALDH1A1KDM4E | |
| SCHEMBL3095157 | 0.91 | HDAC1 (0.86) | HDAC1HDAC3HDAC2ALDH1A1KDM4E | |
| SCHEMBL3102662 | 0.90 | HDAC1 (0.82) | HDAC1HDAC3HDAC2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238103-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-10-13 | — | — | EP | disclosed |
| US-7795315-B2 | N-(2-amino-phenyl)-amide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20090203681-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | US | disclosed |
| WO-2009095324-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203681-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | MKI67, API5, BAD | HDAC1 815/4885HDAC3 1401/4885HDAC2 973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.