Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.73 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30984197 | 0.94 | WRN (0.67) | WRNPOLBL3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL30984157 | 0.93 | WRN (0.66) | WRNACHEPOLBL3MBTL1 | |
| SCHEMBL30984224 | 0.91 | WRN (0.61) | WRN | |
| SCHEMBL30984283 | 0.90 | WRN (0.60) | WRN | |
| SCHEMBL27379033 | 0.90 | WRN (0.79) | WRNACHEPOLBL3MBTL1HSD17B10 | |
| SCHEMBL31394634 | 0.90 | WRN (0.79) | WRNACHEPOLBL3MBTL1HSD17B10 | |
| SCHEMBL25035189 | 0.89 | WRN (0.74) | WRNACHEPOLBL3MBTL1HSD17B10 | |
| SCHEMBL30037352 | 0.89 | WRN (0.74) | WRNACHEPOLBL3MBTL1HSD17B10 | |
| SCHEMBL31394301 | 0.89 | WRN (0.74) | WRNACHEPOLBL3MBTL1HSD17B10 | |
| SCHEMBL31394623 | 0.89 | WRN (0.78) | WRNACHEPOLBL3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153155-A1 | DOUBLE-HETEROCYCLIC WRN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 成都微芯药业有限公司 | 2024-07-25 | — | — | WO | disclosed |