⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500863 | 0.76 | — | — | |
| SCHEMBL13819803 | 0.67 | MAPT (0.43) | — | |
| SCHEMBL207336 | 0.61 | MEN1 (0.30) | — | |
| SCHEMBL10481648 | 0.60 | — | — | |
| SCHEMBL3098903 | 0.60 | GRK6 (0.32) | — | |
| SCHEMBL453813 | 0.59 | — | — | |
| SCHEMBL107508 | 0.59 | GAA (0.36) | — | |
| SCHEMBL30373279 | 0.58 | — | — | |
| SCHEMBL5487950 | 0.58 | — | — | |
| SCHEMBL20307 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. | 2010-09-16 | — | — | US | disclosed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |