Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 9/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 9/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29341732 | 0.87 | ESR2 (0.39) | PDCD1CD274MAPTKMT2AKDM4E | |
| SCHEMBL12706735 | 0.86 | MAPT (0.43) | PDCD1CD274MAPTKMT2AKDM4E | |
| SCHEMBL30989180 | 0.85 | PDCD1 (0.44) | PDCD1CD274MAPTKMT2AKDM4E | |
| SCHEMBL22966561 | 0.85 | PDCD1 (0.40) | PDCD1CD274MAPTKMT2AKDM4E | |
| SCHEMBL30989182 | 0.83 | KDM4E (0.48) | PDCD1CD274MAPTKMT2AKDM4E | |
| SCHEMBL12706832 | 0.82 | PDCD1 (0.45) | PDCD1CD274KMT2AKDM4EMEN1 | |
| SCHEMBL29341216 | 0.82 | ESR2 (0.36) | PDCD1CD274MAPTKMT2AKDM4E | |
| SCHEMBL29341223 | 0.80 | ESR2 (0.34) | PDCD1CD274MAPTKMT2AKDM4E | |
| SCHEMBL3985607 | 0.80 | ESR2 (0.55) | MAPTPARP1PARP2 | |
| SCHEMBL29676623 | 0.80 | ESR2 (0.55) | MAPTPARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4556465-A1 | NOVEL BICYCLIC PD-L1 INHIBITORS, PREPARATION METHODS THEREFOR AND MEDICINAL USES THEREOF | Xi'an Xintong Pharmaceutical Research Co., Ltd. (CN) | 2025-05-21 | — | — | EP | disclosed |
| CN-119768390-A | Novel bicyclo PD-L1 inhibitor and preparation method and medical application thereof | 西安新通药物研究股份有限公司 | 2025-04-04 | — | — | CN | disclosed |
| WO-2024109462-A1 | NOVEL BICYCLIC PD-L1 INHIBITORS, PREPARATION METHODS THEREFOR AND MEDICINAL USES THEREOF | 西安新通药物研究股份有限公司 | 2024-05-30 | — | — | WO | disclosed |