Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.44 |
| ▸ | GPR6 | P46095 | 4/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30990011 | 1.00 | PIK3C3 (0.44) | PIK3C3GPR6TRPM8CES2CES1 | |
| SCHEMBL30989809 | 0.89 | PIK3C3 (0.39) | PIK3C3GPR6SCN9AGPBAR1PTGER4 | |
| SCHEMBL30989919 | 0.89 | PIK3C3 (0.38) | PIK3C3GPR6CES2CES1GPBAR1 | |
| SCHEMBL30989878 | 0.89 | PIK3C3 (0.38) | PIK3C3GPR6CES2CES1GPBAR1 | |
| SCHEMBL30989899 | 0.87 | PIK3C3 (0.39) | PIK3C3GPR6CES2CES1SCN9A | |
| SCHEMBL30989854 | 0.86 | PIK3C3 (0.37) | PIK3C3GPR6GPBAR1RIPK1 | |
| SCHEMBL30989737 | 0.86 | PIK3C3 (0.37) | PIK3C3GPR6GPBAR1RIPK1 | |
| SCHEMBL30989840 | 0.84 | PIK3C3 (0.37) | PIK3C3GPR6GPBAR1RIPK1 | |
| SCHEMBL30989946 | 0.84 | PIK3C3 (0.37) | PIK3C3GPR6GPBAR1RIPK1 | |
| SCHEMBL30990044 | 0.82 | MAPK1 (0.41) | PIK3C3GPR6GPBAR1PTGER4MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |