Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 20/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HCK | P08631 | 1/20 | 0.51 |
| ▸ | FGR | P09769 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30990464 | 0.86 | RET (0.56) | RETKDRCYP1A2HCKFGR | |
| SCHEMBL30990487 | 0.83 | RET (0.60) | RETKDRCYP1A2HCKFGR | |
| SCHEMBL21178733 | 0.82 | RET (0.59) | RETKDRCYP1A2HCKFGR | |
| SCHEMBL30990474 | 0.79 | RET (0.61) | RETKDRCYP1A2HCKFGR | |
| SCHEMBL21184989 | 0.77 | RET (0.69) | RETKDRCYP1A2HCKFGR | |
| SCHEMBL30990439 | 0.76 | RET (0.58) | RETKDRCYP1A2HCKFGR | |
| SCHEMBL21179095 | 0.76 | RET (0.57) | RETKDRCYP1A2HCKFGR | |
| SCHEMBL21179101 | 0.76 | RET (0.69) | RETKDRCYP1A2HCKFGR | |
| SCHEMBL21179092 | 0.76 | RET (0.69) | RETKDRCYP1A2HCKFGR | |
| SCHEMBL31639823 | 0.76 | RET (0.60) | RETKDRCYP1A2HCKFGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665720-A2 | ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173832-A2 | ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |