Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | PIM1 | P11309 | 1/20 | 0.67 |
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL148815 | 0.96 | KDM4E (0.69) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL990067 | 0.96 | KDM4E (0.69) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL4447230 | 0.96 | KDM4E (0.69) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL1812577 | 0.96 | KDM4E (0.69) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL18428500 | 0.96 | KDM4E (0.69) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL5839066 | 0.96 | KDM4E (0.69) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL19611842 | 0.96 | KDM4E (0.69) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL10792204 | 0.96 | KDM4E (0.69) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL11763477 | 0.96 | KDM4E (0.69) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL16968195 | 0.96 | KDM4E (0.69) | KDM4EKMT2APIM1METAP2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100183874-A1 | PRIMER HAVING A HOT-MELT ADHESIVE COMPOSITION | SIKA TECHNOLOGY AG (CH) | 2010-07-22 | — | — | US | disclosed |