Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tivozanib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 20/20 | 0.98 |
| ▸ | FLT1 known ✓ | P17948 | 4/20 | 0.98 |
| ▸ | FLT4 known ✓ | P35916 | 4/20 | 0.98 |
| ▸ | KIT known ✓ | P10721 | 3/20 | 0.98 |
| ▸ | PDGFRB known ✓ | P09619 | 2/20 | 0.98 |
| ▸ | PDGFRA | P16234 | 12/20 | 0.98 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.98 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.98 |
| ▸ | STK10 | O94804 | 2/20 | 0.98 |
| ▸ | ABL1 | P00519 | 2/20 | 0.98 |
| ▸ | RET | P07949 | 2/20 | 0.98 |
| ▸ | BCR | P11274 | 2/20 | 0.98 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.98 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.98 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.98 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.98 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.98 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.98 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.98 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tivozanib SCHEMBL1869882 | 1.00 | KDR (0.98) | KDRPDGFRAFLT1FLT4KIT | |
| Tivozanib SCHEMBL21174286 | 0.99 | KDR (0.97) | KDRPDGFRAFLT1FLT4KIT | |
| Tivozanib SCHEMBL29394095 | 0.99 | KDR (0.97) | KDRPDGFRAFLT1FLT4KIT | |
| Tivozanib SCHEMBL29354604 | 0.99 | KDR (1.00) | KDRPDGFRAFLT1FLT4KIT | |
| Tivozanib SCHEMBL172883 | 0.99 | KDR (1.00) | KDRPDGFRAFLT1FLT4KIT | |
| Tivozanib SCHEMBL29354238 | 0.99 | KDR (1.00) | KDRPDGFRAFLT1FLT4KIT | |
| Tivozanib SCHEMBL5214691 | 0.96 | KDR (0.93) | KDRPDGFRAFLT1FLT4KIT | |
| Tivozanib SCHEMBL5209537 | 0.96 | KDR (0.93) | KDRPDGFRAFLT1FLT4KIT | |
| Tivozanib SCHEMBL5211590 | 0.94 | KDR (0.90) | KDRPDGFRAFLT1FLT4KIT | |
| Tivozanib SCHEMBL5545131 | 0.94 | KDR (0.90) | KDRPDGFRAFLT1FLT4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4654968-A1 | PROCESS FOR THE PREPARATION OF TIVOZANIB OR A SALT THEREOF | Alivus Life Sciences Limited (IN) | 2025-12-03 | — | — | EP | disclosed |
| WO-2024157170-A1 | PROCESS FOR THE PREPARATION OF TIVOZANIB OR A SALT THEREOF | GLENMARK LIFE SCIENCES LIMITED (IN) | 2024-08-02 | — | — | WO | disclosed |