Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | GRK2 | P25098 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28476884 | 1.00 | KDM4C (0.38) | KDM4CKDM5AKDM5BLATS1AAK1 | |
| SCHEMBL28476883 | 1.00 | KDM4C (0.38) | KDM4CKDM5AKDM5BLATS1AAK1 | |
| SCHEMBL30995685 | 0.90 | KDM4C (0.40) | KDM4CKDM5AKDM5BLATS1AAK1 | |
| SCHEMBL28486636 | 0.90 | KDM4C (0.40) | KDM4CKDM5AKDM5BLATS1AAK1 | |
| SCHEMBL28486638 | 0.90 | KDM4C (0.40) | KDM4CKDM5AKDM5BLATS1AAK1 | |
| SCHEMBL28483551 | 0.84 | KDM4C (0.38) | KDM4CKDM5AKDM5BF2SIGMAR1 | |
| SCHEMBL20137432 | 0.84 | KDM4C (0.38) | KDM4CKDM5AKDM5BF2SIGMAR1 | |
| SCHEMBL20137431 | 0.82 | KMT2A (0.47) | KDM4CKDM5AKDM5B | |
| SCHEMBL30995679 | 0.82 | KMT2A (0.47) | KDM4CKDM5AKDM5B | |
| SCHEMBL20137430 | 0.82 | KMT2A (0.47) | KDM4CKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12006323-B2 | Ethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2024-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12006323-B2 | Ethynyl derivatives | GRM4, GRM2, GRIA4 | KDM4C 3493/4885KDM5A 3934/4885KDM5B 3781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.