Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 4/20 | 0.42 |
| ▸ | GABRD | O14764 | 4/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.42 |
| ▸ | GABRE | P78334 | 4/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.42 |
| ▸ | ASPH | Q12797 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436030 | 0.88 | KDM4E (0.40) | KDM4EMAPTCYP1A2GABRPGABRD | |
| SCHEMBL20579524 | 0.85 | MAP2K3 (0.40) | KDM4ECYP1A2GABRPGABRDGABRA1 | |
| SCHEMBL29865435 | 0.81 | BRD4 (0.47) | KDM4EMAPTCYP1A2ALOX15L3MBTL1 | |
| SCHEMBL23137481 | 0.80 | PRKCI (0.35) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL14895438 | 0.80 | BRD4 (0.48) | KDM4EMAPTCYP1A2ALOX15L3MBTL1 | |
| SCHEMBL10694897 | 0.79 | KDM4E (0.47) | KDM4EMAPTCYP1A2GABRPGABRD | |
| SCHEMBL29099630 | 0.79 | KDM4E (0.44) | KDM4EMAPTCYP1A2GABRPGABRD | |
| SCHEMBL5820837 | 0.79 | KDM4E (0.44) | KDM4EMAPTCYP1A2GABRPGABRD | |
| SCHEMBL868001 | 0.79 | KDM4E (0.44) | KDM4EMAPTCYP1A2GABRPGABRD | |
| SCHEMBL8645026 | 0.78 | KDM4E (0.46) | KDM4EMAPTCYP1A2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4646271-A1 | SUBSTITUTED SPIROCYCLIC-PYRROLOQUINAZOLINONES AND SPIROCYCLIC-PIPERIDINOQUINAZOLINONES | Mirati Therapeutics, Inc. (US) | 2025-11-12 | — | — | EP | disclosed |
| WO-2024148150-A1 | SUBSTITUTED SPIROCYCLIC-PYRROLOQUINAZOLINONES AND SPIROCYCLIC-PIPERIDINOQUINAZOLINONES | Mirati Therapeutics, Inc. (US) | 2024-07-11 | — | — | WO | disclosed |