Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | KDM6B | O15054 | 2/20 | 0.57 |
| ▸ | KDM5C | P41229 | 2/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.57 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.57 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.57 |
| ▸ | JMJD6 | Q6NYC1 | 4/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18038178 | 1.00 | KDM4E (0.57) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL30162994 | 0.85 | KDM5C (0.52) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL29218273 | 0.85 | KDM5C (0.52) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL20029719 | 0.83 | KDM4E (0.53) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL18038188 | 0.83 | KDM4E (0.44) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL1758980 | 0.81 | KDM4E (0.57) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL29218201 | 0.80 | KDM4E (0.63) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL30163064 | 0.80 | KDM4E (0.63) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL27137907 | 0.80 | NPC1 (0.50) | NPC1RAB9A | |
| SCHEMBL70279 | 0.79 | KDM4E (0.86) | KDM4EKDM6BKDM5CKDM4CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |