Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.54 |
| ▸ | FLT3 | P36888 | 12/20 | 0.54 |
| ▸ | IRAK1 | P51617 | 4/20 | 0.54 |
| ▸ | LCK | P06239 | 3/20 | 0.54 |
| ▸ | RET | P07949 | 3/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.54 |
| ▸ | CDK7 | P50613 | 3/20 | 0.54 |
| ▸ | CCNH | P51946 | 3/20 | 0.54 |
| ▸ | BLK | P51451 | 2/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.54 |
| ▸ | NRAS | P01111 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10239892 | 0.91 | FLT3 (0.57) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL376565 | 0.89 | FLT3 (0.58) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL24976224 | 0.87 | FLT3 (0.50) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL24975679 | 0.87 | FLT3 (0.50) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL30248355 | 0.87 | FLT3 (0.50) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL31000113 | 0.86 | IRAK4 (0.51) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL25989138 | 0.85 | IRAK4 (0.52) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL25998143 | 0.85 | IRAK4 (0.52) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL25992854 | 0.85 | IRAK4 (0.52) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL25989139 | 0.85 | IRAK4 (0.52) | IRAK4FLT3IRAK1LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |